Doug Greenberg covers sport betting for ESPN. He previously covered sports betting, sports business and fantasy sports at Front Office Sports, VSiN and RotoWire. He lives in Chicago after growing up in Boston.
The second game of the 2026 NFL season produced something of a stunner, with the Los Angeles Rams falling to the San Francisco 49ers 27-7, the biggest loss for a preseason Super Bowl favorite in its opener on record. In turn, the Rams moved from +500 to +600 and now sit at +650 on the championship odds board, while the Niners made a big jump from 19-1 to 14-1.
The result also had implications for the NFC West rival and defending Super Bowl champion Seattle Seahawks, who opened the season with a win over the New England Patriots (21-1). That victory shortened Seattle from 12-1 to 11-1 for the title.
The Baltimore Ravens are second on the board at +900, followed by the Buffalo Bills at +950. There are 17 teams with odds of 25-1 or shorter to win Super Bowl LXI.
and subject to change.