Scotland will have two captains and four uncapped players on the field when they kick off their autumn international test against Tonga at Murrayfield on Saturday.
After two years apart, the elite rugby nations of the northern and southern hemispheres will reunite throughout November, providing a valuable marker two years out from the next global showpiece. Here's what you need to know.
Scotland captain Stuart Hogg has lost five kilograms in a bid to improve his physical and mental health after feeling "drained" following the British & Irish Lions series defeat in South Africa.
Wallabies coach Dave Rennie has been left sweating the fitness of star centre Samu Kerevi after the 28-year-old hobbled off the field in the Wallabies 32-17 win over Argentina on Saturday night.
Disruption isn't always bad, especially when it comes to the old guard that largely continues to govern the rugby world. But is shoehorning in another format, this time the World 12s, really an answer to the game's issues?
Scotland's test against Georgia in Tbilisi next Saturday has been cancelled after their hosts reported six positive COVID-19 cases while in South Africa this week.
England Rugby, Scottish Rugby, and Wales Rugby said on Thursday they would join football and other sports' social media blackout this weekend in a show of solidarity against online abuse.
Scotland's Hamish Watson secured 35% of more than 125,000 votes cast by fans to claim the 2021 Six Nations player of the championship.
Scotland's Jonny Gray and Sean Maitland will miss the trip to the Stade de France for the Six Nations finale on Friday.
Scotland ran in eight tries to ensure a record 52-10 victory over Italy at Murrayfield on Saturday and a return to winning ways after successive narrow defeats in the Six Nations.
As the final round of the 2021 Six Nations approaches, Wayne Pivac's Wales side are on the verge of history as they chase the Grand Slam. Tom Hamilton previews what's at stake in this weekend's games.
Johnny Sexton steered Ireland to a 27-24 victory over Scotland at Murrayfield on Sunday, grinding down a sparkling but indisciplined home side.
Tom Hamilton is back to help you out with your ESPN Pick'em choices as the Six Nations return this weekend.
Jamison Gibson Park will start at scrum-half ahead of Conor Murray for Ireland's match against Scotland in the Six Nations on Sunday.
Centre Sam Johnson starts his first match of the 2021 Six Nations when Scotland welcome Ireland to Murrayfield on Sunday.
There are just two Six Nations games this weekend due to COVID-19 but ESPN's Pick 'em goes ahead regardless and Tom Hamilton has your top picks for Round 3.
France's Six Nations match against Scotland in Paris will go ahead on Sunday as planned after the hosts reported no further positive COVID-19 tests for a second consecutive day, organisers said on Wednesday.
France's star scrum-half Antoine Dupont and four other first-team players who tested positive for COVID-19 are out of the squad for next Sunday's Six Nations match against Scotland.
French players Antoine Dupont, Gabin Villiere and Mohamed Haouas have all returned positive COVID-19 tests ahead of their Six Nations clash against Scotland.
Scotland prop Zander Fagerson will miss Six Nations matches against France, Ireland and Italy, along with one further game yet to be determined.
Wales roared back from a 17-3 half time deficit to complete a remarkable 25-24 Six Nations win over Scotland on Saturday.
After an opening weekend which blew many predictions out of the water, Tom Hamilton breaks down your top choices for Week 2 of ESPN's Rugby Pick'em.
Cameron Redpath, Jamie Ritchie and Sean Maitland are all absent through injury so Blade Thomson, James Lang and Darcy Graham all start for Scotland at Murrayfield on Saturday.
Wales battle a growing injury list and call up Aaron Wainright, Gareth Davies, Liam Williams, Nick Tompkins and Owen Watkin to start in their upcoming Six Nations game against Scotland.
Italy have called up Pierre Bruno and Andrea Lovotti for the upcoming Six Nations clash against England after Marco Zanon was ruled out due to injury.
- SCOT2ndTries Scored 1st Wales : 20 Tries ScoredWALES1st1820
- SCOT3rdPoints Difference 1st Wales : 61 Points DifferenceWALES1st4761