But the opening round brought injuries, too.
Heading into Week 2, Ireland face Italy but must do so without Peter O'Mahony, who became the first to succeed retired legend Johnny Sexton as captain last weekend but is now ruled out through injury, meaning Caelan Doris will lead the side.
Meanwhile, England will face Wales at Twickenham with an unchanged side, although the visitors will take strength from the return of George North.
Here's the latest team news and everything you need to know heading into the weekend.
Scotland vs. France, Saturday, 2.15pm GMT, Murrayfield, Edinburgh
Co-Captain Rory Darge and second-row Grant Gilchrist will return for Scotland on Saturday as they host France.
They replace the injured back-row Luke Crosbie and lock Richie Gray, who will both miss the rest of the tournament after sustaining injuries in their opening win over Wales, Scottish Rugby said on Tuesday.
Crosbie suffered a shoulder injury and Gray is ruled out with a bicep issue.
Scotland claimed a dramatic first win in Cardiff for 22 years after withstanding a remarkable fightback from Wales to seal a 27-26 victory on Saturday.
Winger Darcy Graham and prop WP Nel are recovering well from their injuries and will both resume training with Edinburgh this week, Scottish Rugby's statement added.
Meanwhile, France have made two changes to the side that lost 38-18 to Ireland in Marseille last week.
Paul Willemse has been handed a four-week suspension after he was shown a red card for two high tackles. Cameron Woki comes in to replace him at lock.
In the backs, Louis Bielle-Biarrey replaces Yoram Moefana on the left wing in the only other change in in the starting team. Kyle Steyn dropped out of the team late, replaced by Harry Paterson, as Steyn's wife went into the labour with his child.
Sebastien Taofifenua is back on the bench after his withdrawal before the Ireland game due to illness, while uncapped flanker Alexandre Roumat is named among the replacements. Reda Wardi out after his wrist injury sustained in the game.
Scotland face France in their second game on Saturday.
Scotland: Harry Paterson, Kyle Rowe, Huw Jones, Sione Tuipulotu, Sione Tuipulotu, Duhan van der Merwe, Finn Russell, Ben White, Jack Dempsey, Rory Darge, Matt Fagerson, Scott Cummings, Grant Gilchrist, Zander Fagerson, George Turner, Pierre Schoeman.
Replacements: Ewan Ashman, Alec Hepburn, Elliot Millar-Mills, Sam Skinner, Andy Christie, George Horne, Ben Healy, Cameron Redpath.
France: Thomas Ramos, Damian Penaud, Gael Fickou, Jonathan Danty, Louis Bielle-Biarrey, Matthieu Jalibert, Maxime Lucu, Gregory Alldritt, Charles Ollivon, Francois Cros, Paul Gabrillagues, Cameron Woki, Uini Atonio, Peato Mauvaka, Cyril Baille.
Replacements: Julien Marchand, Sebastien Taofifenua, Dorian Aldegheri, Posolo Tuilagi, Alexandre Roumat, Paul Boudehent, Nolann Le Garrec, Yoram Moefana.
England vs. Wales, Saturday, 4.45pm Twickenham, London
England head coach Steve Borthwick has named an unchanged starting XV, although Ellis Genge does return as an option on the bench as they look to build on their opening victory.
Beno Obano drops out of the squad for Genge, who was a late injury withdrawal before the game against Italy.
Wales are seeking a first Six Nations victory at Twickenham since 2012 and have been handed a boost with George North in line for his 50th tournament appearance, taking a place in the midfield alongside Nick Tompkins.
"This is a massive game, not only because of the history and what it means to everyone in Wales. But it's an opportunity to get things on track a bit more," head coach Warren Gatland said in a statement.
Fly-half Sam Costelow has been ruled out after he was injured in last week's defeat to Scotland in Cardiff. Ioan Lloyd of Scarlets will replace him in the No. 10 jersey.
Alex Mann will make his first senior international start having been named at blind-side flanker.
Wales have released flanker James Botham from their squad due to a knee injury.
Botham, the grandson of former England cricket all-rounder Ian, sparked Wales' remarkable comeback against Scotland on Saturday.
The length of his absence is unknown, with Welsh Rugby confirming he will return to his club Cardiff to continue his rehabilitation.
Wales do have two other tightheads in Keiron Assiratti, who has three international appearances, and uncapped Archie Griffin. Lewis is a veteran of 54 caps and adds experience in that position.
England: Freddie Steward, Tommy Freeman, Henry Slade, Fraser Dingwall, Elliot Daly, George Ford, Alex Mitchell; Joe Marler, Jamie George, Will Stuart, Maro Itoje, Ollie Chessum, Ethan Roots, Sam Underhill, Ben Earl.
Replacements: Theo Dan, Ellis Genge, Dan Cole, Alex Coles, Chandler Cunningham-Smith, Danny Care, Fin Smith, Immanuel Feyi-Waboso.
Wales: Cameron Winnett, Josh Adams, George North, Nick Tompkins, Rio Dyer, Ioan Lloyd, Tomos Williams, Aaron Wainwright, Tommy Reffell, Alex Mann, Dafydd Jenkins, Keiron Assiratti, Elliot Dee, Gareth Thomas.
Replacements: Ryan Elias, Corey Domachowski, Archie Griffin, Will Rowlands, Taine Basham, Kieran Hardy, Cai Evans, Mason Grady.
Ireland vs. Italy, Sunday 3pm, Aviva Stadium, Dublin
Ireland captain Peter O'Mahony has been left out of coach Andy Farrell's squad after picking up an injury against France last weekend.
Caelan Doris will captain Farrell's side for the first time, becoming the 110th player to captain the Ireland men's team in Test rugby.
Stuart McCloskey comes into the midfield in place of Bundee Aki, who also drops out of the matchday squad.
Centre Garry Ringrose has not recovered from a shoulder injury in time to take his place in the squad, with assistant coach Mike Catt suggesting he was making good progress this week. He will now look to Ireland's game against Wales on Feb. 24.
Jack Crowley retains his place at fly-half, while his Munster teammate Craig Casey lines up next to him at scrum-half.
Andrew Porter, Dan Sheehan and Finlay Bealham start in the front-row, with James Ryan coming into the starting XV to partner Joe McCarthy in the second row.
Ryan Baird is named at blindside flanker, Doris shifts to openside and Jack Conan starts at No. 8.
For Italy, head coach Gonzalo Quesada has made four changes to the side that lost to England on the opening weekend.
Ange Capuozzo starts at full-back after recovering from a stomach bug. Stephen Varney replaces Alessandro Garbisi at scrum-half.
Sebastian Negri has been ruled out with an injury, Alessandro Izekor replaces him in the back-row.
Manuel Zulani also starts in the back-row, replacing the injured Lorenzo Cannone.
Ireland: Hugo Keenan, Calvin Nash, Robbie Henshaw, Stuart McCloskey, James Lowe, Jack Crowley, Craig Casey, Jack Conan, Caelan Doris, Ryan Baird, James Ryan, Joe McCarthy, Finlay Bealham, Dan Sheehan, Andrew Porter.
Replacements: Ronan Kelleher, Jeremy Loughman, Tom O'Toole, Iain Henderson, Josh van der Flier, Jamison Gibson-Park, Harry Byrne, Jordan Larmour.
Italy: Ange Capuozzo, Lorenzo Pani, Juan Ignacio Brex, Tommaso Menoncello, Montanna Ioane, Paolo Garbisi, Stephen Varney, Danilo Fischetti, Gianmarco Lucchesi, Pietro Ceccarelli, Niccolo Cannone, Federico Ruzza, Alessandro Izekor, Manuel Zulani, Michele Lamaro.
Replacements: Giacomo Nicotera, Mirco Spagnolo, Giosue Zilocchi, Andrea Zambonin, Ross Vintcent, Martin Page-Relo, Tommaso Allan, Federico Mori.