Scotland have made three changes for Wales from the side that secured their famous win against England.
Cameron Redpath, Jamie Ritchie and Sean Maitland are all absent through injury so Blade Thomson, James Lang and Darcy Graham all start for Scotland at Murrayfield on Saturday.
"We have an opportunity this weekend against Wales to continue the positive start to the Guinness Six Nations we made last week against England," Scotland boss Gregor Townsend said.
"It was a very encouraging performance at Twickenham and the squad performed to a level which has to be the benchmark throughout the tournament.
"Wales are also coming into this game after a win and will have the same objective, so it will be a tough challenge as always.
"Both teams were involved in physical contests last weekend, and that is evidenced by the injuries Wales and we ourselves have picked up.
"For us, we are able to bring in three quality players in Blade, James and Darcy. They have been training well and are highly motivated to make the most of this opportunity."
Scotland Starting XV:
Stuart Hogg (captain), Darcy Graham, Chris Harris, James Lang, Duhan Van der Merwe, Finn Russell, Ali Price; Rory Sutherland, George Turner, Zander Fagerson, Scott Cummings, Jonny Gray, Blade Thomson, Hamish Watson, Matt Fagerson.
David Cherry, Oli Kebble, WP Nel, Richie Gray, Gary Graham, Scott Steele, Jaco Van der Walt, Huw Jones.