Making his first career playoff start, Wentz lasted two series before exiting with a head injury following a helmet-to-helmet hit from Clowney.
Nick Foles wasn't around to rescue Philadelphia this time.
Forty-year-old Josh McCown stepped in, becoming the oldest quarterback to make his playoff debut. But he couldn't lead the Eagles (9-8) into the end zone.
The Seahawks (12-5) lost three of their final four games, including a 26-21 defeat at home against San Francisco in Week 17 that cost them the NFC West title.
But they traveled to Philadelphia for the second time in six weeks and became the third team to win on the road this weekend, improving to 8-1 away from home this season.
Wilson threw for 325 yards and led the team with 45 yards rushing. Metcalf had seven catches for 160 yards.
The Seahawks had a season-high seven sacks from six players.
Wilson drove Seattle 82 yards late in the second quarter and Lynch powered in from the 5 for a 10-0 lead.
Wilson connected with Metcalf for 26 yards and David Moore for 38 on third-down, catch-and-run passes to keep that drive going.
McCown finally got the offense going on the opening drive of the third quarter. He connected with Zach Ertz for 32 yards and Boston Scott ran 15 yards to the 5. But a false start, fumbled snap and sack followed. Jake Elliott's 26-yard field goal cut the deficit to 10-6.
The Seahawks answered quickly. Metcalf stretched to catch Wilson's deep pass, got up and tumbled into the end zone for a 17-6 lead.
Down 17-9, Eagles coach Doug Pederson passed up a 42-yard field goal attempt with 6:24 left and went for fourth-and-4 from the Seahawks 24. Miles Sanders couldn't catch McCown's pass.
Philadelphia had another chance after Shelton Gibson, just signed earlier in the week, drew a 39-yard pass interference penalty to the Seahawks 13.
On fourth-and-7 from the 10 with two minutes left, Clowney sacked McCown.
Wentz was forced to watch from the sideline following knee surgery when Foles led the Eagles to the franchise's first Super Bowl title two years ago. He was out with a back injury last year when Foles led Philadelphia to a wild-card win in Chicago.
The Eagles were decimated by injuries throughout the season and had to rely on five offensive players off the practice squad during a four-game winning streak that sealed the NFC East title.
Wentz started all 16 games for the second time in his four seasons and played his best down the stretch with backups surrounding him. But he finished the season injured the same as the previous two.
Seattle had plenty of injuries, too. The Seahawks lost running backs Chris Carson, Rashaad Penny and C.J. Prosise, forcing them to sign Lynch.
But Seattle has Wilson -- and he has the Seahawks heading to Green Bay in the divisional round.
The Seahawks also beat the Eagles 17-9 on Nov. 24.
Seahawks: Defensive tackle Ziggy Ansah left with a neck injury.
Eagles: Wentz stayed in the game after the shot from Clowney, threw two passes and left for the locker room late in the first quarter. ... Defensive end Brandon Graham left with a knee injury.
Seahawks: Will go to Green Bay to face Aaron Rodgers and the Packers (13-3) in the divisional round next Sunday.
Eagles: Start the offseason.
More AP NFL: https://apnews.com/NFL and https://twitter.com/AP-NFL
- Derick Bowers
- Jeff Lamberth
- Tim Podraza
- Tony Steratore
- Keith Washington
- Bryan Neale
- Shawn Smith