Thomas Partey's long-range shot gave Ghana the lead and 19-year-old debutant Mohammed Kudus added the second in a 2-0 home win over South Africa.
Senegal eased to a 2-0 win over Congo while Nigeria could only scrape a 2-1 victory over Benin in the opening day of 2021 AFCON qualifiers.
Nigeria overcame a scare from Benin to eke out a win in their opening 2021 Africa Cup of Nations qualifier. Here are three takeaways from the game
Respective coaches James Kwesi Appiah and Molefi Ntseki will be under intense scrutiny when Ghana and South Africa clash.
When your day job is managing thousands of lives in criss-crossing aircraft across a continent, managing a football team holds few terrors.
Wednesday's group stage openers mark the proper kickoff for the Cameroon 2021 campaign, less than four months after the 2019 final.
Mohamed Salah has been ruled out of Egypt's African Cup of Nations qualifiers, and was pictured wearing a protective boot on his ankle.
Starting this Africa Cup of Nations campaign with anything other than a win against Benin is not a scenario that can be countenanced in Nigeria,.
South Sudan's long road to AFCON 2021 begins next week. Remarkably, 12 players will travel 7,000 miles from Australia to play for the Bright Stars.
The French coach is confident the region is beginning to realise its untapped football potential.
The Nigerian legend says African coaches "can do much more if there is support from everyone instead of running to Europeans at every opportunity".
Some of the continent's less-heralded sides have made the most of the Africa Cup of Nations' expanded format.
A 1-1 draw at home to Gabon in Bujumbura on Saturday ensured qualification for Burundi, sparking wild celebrations.
Burundi qualified for the Africa Cup of Nations for the first time on Saturday, and they were joined by Cameroon, Guinea Bissau and Namibia.
Given the lack of pressure in facing Seychelles on Friday, having already qualified for the Africa Cup of Nations, Nigeria's display was... meh.
Angola striker Wilson Eduardo scored on his debut as they beat Botswana 1-0 to qualify for the expanded 24-team Africa Cup of Nations finals.
Ahead of the final round of Africa Cup of Nations qualifiers, 14 teams have already qualified, and South Africa should really be among them.
Nigeria have never been short of inspiration for international games, and coach Gernot Rohr wants them to be mentally tough against tiny Seychelles.
Here's the state of play heading into the final round of Africa Cup of Nations qualifiers, with 10 of the 24 berths in the finals up for grabs.
The final round of Africa Cup of Nations qualifiers runs from 22 to 24 March. Which teams have opted to rest some of their biggest stars?
Nigeria's captain has not been involved with the Super Eagles since the World Cup in Russia. But the team does not appear to have missed its leader.
South Africa are second in Group E, two points ahead of Libya, and need only to draw the fixture in Sfax, Tunisia, to secure AFCON qualification.
Uganda are targeting a spot at the 2026 World Cup after qualifying for back-to-back Africa Cup of Nations tournaments, according to FUFA.
Where did it all go wrong for the Warriors in Liberia, and what must they get right in order to get over the line and reach the AFCON?
To miss one open goal is unfortunate, but to miss two just moments apart is... well, just ask Lesotho forward Tumelo Khutlang.
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