Ciro Immobile's hat-trick inspired Lazio to a 6-1 thrashing of Spezia as the Rome club made it two wins from two at the start of the new season.
Two goals from Victor Osimhen helped Napoli climb to second in the Serie A standings after a comprehensive 4-1 win at Spezia on Saturday.
Ivan Perisic's equaliser earned Inter Milan a 1-1 draw at Spezia on Wednesday to move Antonio Conte's side one step closer to the Serie A title.
Spezia secured a huge win for their Serie A survival hopes by beating relegation rivals Cagliari 2-1 on Saturday.
Atalanta's Mario Pasalic bagged a double and Luis Muriel scored a superb goal as the hosts beat lowly Spezia 3-1 on Friday.
Cristiano Ronaldo marked his 600th league appearance with his 20th Serie A goal of the season as Juventus beat Spezia 3-0 on Tuesday.
Spezia felled another Serie A giant as they shocked league leaders AC Milan with a dominant display in a 2-0 victory on Saturday.
A stoppage-time winner from Lorenzo Pellegrini sealed a 4-3 Serie A win for AS Roma against Spezia on Saturday.
AS Roma manager Paulo Fonseca said he was unaware of a substitutions mix-up in Tuesday's Coppa Italia defeat by Spezia after making six changes.
Spezia came from behind to earn a shock smash-and-grab 2-1 win at Napoli in Serie A on Wednesday despite being reduced to 10 men.
Second-placed Inter Milan needed second-half goals from Achraf Hakimi and leading scorer Romelu Lukaku to overcome stubborn resistance from Spezia.
Cristiano Ronaldo made an immediate impact on his return from a COVID-19 infection on Sunday, scoring three minutes after coming on as a substitute.
Promoted Spezia squandered a two-goal lead, hit the woodwork three times and conceded a penalty in stoppage time as they were held to a 2-2 draw at
Spezia was promoted to Italy's Serie A for the first time on Thursday.
Alberto Gilardino has found himself a new club by joining Spezia Calcio, the Italian Serie B club announced on their website on Tuesday.
A young midfielder at Italy's Serie B club Spezia has turned down the chance to represent his country at the under-20 World Cup in South Korea.
Kwesé Sports brings you Serie B action on Friday evening as Perugia host Spezia live on Kwesé Sports 1.
Napoli cruised into the quarterfinals of the Coppa Italia with a 3-1 win over Spezia on Tuesday night.
Spezia caused an upset by knocking Udinese out of the Coppa Italia on Saturday.
Lega Pro club Alessandria will tackle Italian giants AC Milan in the semifinals of the Coppa Italia.