The Monarchs have claimed victory in 12 of their last 14 games.
Xavier Green added 13 points and five assists for Old Dominion (14-5, 4-2 Conference USA). The Monarchs hit 10 of 26 from 3-point range, 10 of 20 at the free-throw line and outrebounded Southern Miss 45-32.
The Monarchs ended the first half on a 25-7 run for a 40-29 lead after connecting on 7 of 16 from distance.
It was Southern Miss's eighth road game in its last 10 contests.
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Florida lands top graduate transfer Blackshear
Virginia Tech's Kerry Blackshear Jr., the No. 1 graduate transfer in ESPN's transfer rankings, announced Wednesday night that he has committed to Florida.