The Spartans hadn't won since December 29 against an NAIA foe, and had dropped eight straight.
Moore opened the game with a jump shot and two 3-pointers and USC Upstate (6-17, 1-7 Big South) never trailed, held Longwood to six points in the first 10 minutes and led 36-19 at the break. The Big South win was the first ever for the Spartans, who joined the conference this season.
The Spartans were 46 percent shooting from the floor, 28 of 61, and made 12 3-pointers. USC Upstate scored 20 points off 18 Longwood turnovers and had 19 assists.
St. Francis (NY) beats Medgar Evers 122-58
Trey Quartlebaum had 20 points as St. Francis (NY) routed Division III Medgar Evers 122-58 on Thursday night.
Steele scores 20 to lift Duquesne past Indiana St. 74-71
Baylee Steele had a career-high 20 points as Duquesne came from behind to beat Indiana State 74-71 on Thursday night.
Robinson, Omaha beat Washington State 85-77
KJ Robinson scored 18 of his 20 points in the second half, JT Gibson finished with 18 points, and Omaha beat Washington State 85-77 on Thursday night.