Alex Matthews ran for a touchdown early in the game after a William & Mary fumble recovery by Dillon DeIuliis set the Raiders up on the Tribe's 21-yard line. Puzzi followed with a trio of field goals, including one from 47 yards, that gave Colgate a 16-0 lead at halftime.
Shon Mitchell's opening drive fumble was followed by another by wide receiver DeVonte Dedmon early in the second quarter and a Mitchell interception by Colgate's Abu Daramy-Swaray early in the fourth.
Mitchell had 251 yards passing for the Tribe (1-3). Dedmon had 104 yards receiving on 10 catches.
College football power rankings for Week 12
The Tigers moved to the top spot in the rankings after their 26th win in a row.
Slovis’ 4 TD passes lead USC past California 41-17
Kedon Slovis completed 29 of 35 passes for 406 yards and four touchdowns against one of the Pac-12’s top pass defenses, leading Southern California to a 41-17 victory over California on Saturday night.
No. 6 Oregon downs Arizona 34-6 for 9th straight win
Justin Herbert threw for 333 yards and four touchdowns and No. 6 Oregon won its ninth straight game and secured a spot in the Pac-12 championship game with a 34-6 victory over Arizona on Saturday night.
Henderson throws 3 TD passes, No. 21 Broncos beat New Mexico
Jaylon Henderson threw for 292 yards and three touchdowns, Sonatane Lui had two fumble recoveries, including one for a score, and No. 21 Boise State beat New Mexico 42-9 on Saturday night.
Herbert deals 4 TDs vs. Arizona
Justin Herbert goes off for 328 yards and four touchdown passes as Oregon steamrolls Arizona 34-6.
OU rallies from 25 down to stun Baylor, finish historic comeback
Oklahoma kept its College Football Playoff hopes alive by putting together its biggest comeback win in school history.