Wales captain Dan Biggar will make his 100th test appearance when they face Scotland in the Six Nations clash at Cardiff on Saturday, while centre Jonathan Davies is also in line to get his 100th cap from the bench.
Coach Wayne Pivac named his team to take on Scotland on Thursday, which does not include winger Josh Adams after he was ruled out with a tight calf.
"To get a hundred test matches in total for any player from any country, it's just a magnificent achievement," Pivac said on Biggar and Davies.
"It shows the hard work and dedication they have put in and the sacrifice they have made over a number of years to get to this stage.
"I'm very, very happy for both of those players to achieve it and to do it on the same day. They've played a lot of test matches together in the past -- it's just going to be fantastic to see them both out there at some stage."
Flanker Jac Morgan will earn his first senior international cap at openside, while Taine Basham moves to blindside with Ross Moriarty completing the back-row.
Wyn Jones, Ryan Elias, Tomas Francis will be the starting front-row, with Will Rowlands and Adam Beard joining them at lock.
Owen Watkin makes his first start since last year's championship at outside centre, and will link up with Nick Tompkin in the midfield.
Tomos Williams will partner Biggar at scrum-half. Alex Cuthbert joins Louis Rees-Zammit and Liam Williams in the back three, earning his first Six Nations appearance since 2017.
Scotland will have a new front-row for the clash after coach Gregor Townsend made five changes to his starting line-up following their narrow victory over England in their opening match last weekend.
Scotland will start in Cardiff with the front trio who came on to finish last Saturday's game at Murrayfield, with Pierre Schoeman and WP Nel set to line up alongside hooker Stuart McInally from the start this time.
Scotland beat England 20-17 and began the tournament in impressive style.
Sam Skinner replaces Jamie Ritchie on the flank. Ritchie had surgery on a hamstring injury suffered last weekend and will be out for the rest of the Six Nations.
Glasgow Warriors centre Sione Tuipulotu comes in for his third cap in place of Sam Johnson.
Rory Darge will make his debut for his country if he comes off the bench, following an impressive season so far for Warriors.
Information from Reuters contributed to this report.
Liam Williams, Alex Cuthbert, Owen Watkin, Nick Tompkins, Louis Rees-Zammit, Dan Biggar, Tomos Williams, Wyn Jones, Ryan Elias, Tomas Francis, Will Rowlands, Adam Beard, Taine Basham, Jac Morgan, Ross Moriarty
Replacements: Dewi Lake, Gareth Thomas, Dillon Lewis, Seb Davies, Aaron Wainwright, Gareth Davies, Callum Sheedy, Jonathan Davies.
Stuart Hogg, Darcy Graham, Chris Harris, Sione Tuipulotu, Duhan van der Merwe, Finn Russell, Ali Price, Pierre Schoeman, Stuart McInally, WP Nel, Jonny Gray, Grant Gilchrist, Sam Skinner, Hamish Watson, Matt Fagerson - Glasgow Warriors
Replacements: George Turner, Rory Sutherland, Zander Fagerson, Magnus Bradbury, Rory Darge, Ben White, Blair Kinghorn, Cameron Redpath.