Luke Cowan-Dickie and Anthony Watson have been ruled out England's November tests with injury, the Rugby Football Union (RFU) said on Tuesday.
Cowan-Dickie, who has won 31 caps for England, sustained an ankle injury during Exeter Chiefs' Premiership win over Wasps on Saturday, and head coach Eddie Jones has called up Jamie George as a replacement. Meanwhile Watson, who ruptured his ACL joint, will be replaced by Harlequins' Joe Marchant.
Saracens hooker George was among the high-profile names omitted from coach Eddie Jones' 34-man squad for the autumn internationals but has now been recalled before England travel to Jersey on Oct. 25 for a five-day training camp.
When announcing his squad on Monday, Jones had sent a mixed message to the experienced players he had dropped, saying the door was always open but added that "we've drawn a line in the sand after the Lions series and we're looking to produce a younger squad to get ready for the World Cup."
Fellow Saracens Mako and Billy Vunipola remain on the outside, but might take heart from George's recall.
England will take on Tonga on Nov. 6 before taking on Australia on Nov. 13 and South Africa on Nov. 20, with all tests at Twickenham Stadium in London.