Jamison Gibson Park will start at scrum-half ahead of Conor Murray for Ireland's match against Scotland in the Six Nations on Sunday.
Andy Farrell has made three changes to the Ireland squad with the experienced scrum-half Murray on the bench following his return from injury.
Keith Earls replaces Jordan Larmour on the right wing while Cian Healy and Rob Herring are set to start in the pack. Herring replaces hooker Ronan Kelleher while Healy takes Dave Kilcoyne's place in the lineup.
Half-back Jamison Gibson Park takes Murray's place at scrum-half after impressing in the win over Italy in Rome last month. He will partner captain Johnny Sexton while the back-row of Tadhg Beirne, Will Connors and CJ Stander remains unchanged.
Sunday's game also marks a milestone for Stander who is set to win his 50th cap, five years after making his debut against Wales.
Ireland are third in the standings with seven points, behind leaders Wales and second-placed France, while Scotland are fifth. Farrell's side host England in the final game six days later.
Hugo Keenan, Keith Earls, Garry Ringrose, Robbie Henshaw, James Lowe, Jonathan Sexton (captain) Jamison Gibson Park, Cian Healy, Rob Herring, Tadhg Furlong, Iain Henderson, James Ryan, Tadhg Beirne, Will Connors
Replacements: Ronan Kelleher, Dave Kilcoyne, Andrew Porter, Ryan Baird, Jack Conan, Conor Murray, Billy Burns, Jordan Larmour.