Wales coach Wayne Pivac has made four changes to the team to face Scotland on Saturday, with captain Alun Wyn Jones set to equal the world record for Test appearances.
All Black Richie McCaw is the only person to have reached 148 caps but Jones' appearances for Wales and the British and Irish Lions will see him equal that.
Jones' partner in the second-row will be Cory Hill, who makes his first start for Wales since February 2019.
There are two changes to the front-row with Wyn Jones and uncapped WillGriff John joining Ken Owens.
The back-row is unchanged with Ross Moriarity, Justin Tipuric and Josh Navidi keeping their places.
Rhys Webb is the only change to the backline. He partners Dan Biggar at half-back, with Hadleigh Parkes and Nick Tompkins in the midfield. Liam Williams, George North and Leigh Halfpenny make up the back-three.
"Saturday is a great opportunity for us to wrap up the campaign with a big performance at home in Cardiff," Pivac said in a statement.
"We want to finish with the performance we know we can deliver and we have been working hard to get there.
"Alun Wyn is one of the most iconic figures in the game, he is our leader and I'm delighted for him as he continues to set the bar across the game."
Wales starting XV to face Scotland:
Leigh Halfpenny, George North, Nick Tompkins, Hadleigh Parkes, Liam Williams, Dan Biggar, Rhys Webb, Wyn Jones; Ken Owens, WillGriff John, Cory Hill, Alun Wyn Jones, Ross Moriarty, Justin Tipuric, Josh Navidi
Replacements: Ryan Elias, Rhys Carre, Leon Brown, Will Rowlands, Taulupe Faletau, Gareth Davies, Jarrod Evans, Johnny McNicholl