Richard Wigglesworth, Luke Cowan-Dickie in as England lose Ben Youngs

Ben Youngs is a major doubt for the rest of the Six Nations having sustained a nasty injury just nine minutes into England's thrashing of Italy. David Rogers - RFU/Getty Images

England have called up Richard Wigglesworth and front row Luke Cowan-Dickie for their Six Nations clash with Wales as Eddie Jones lost Leicester scrum-half Ben Youngs to a nasty knee injury in the 46-15 Six Nations victory over Italy.

Youngs was forced off after just nine minutes at the Stadio Olimpico on Sunday when his leg was caught at an awkward angle and he will undergo a scan to assess the extent of the damage, with the 28-year-old expected to miss at least Saturday's clash with Wales at Twickenham, if not the rest of the tournament.

The Leicester scrum-half's name was missing from the 32 names summoned to England's Surrey traing base on Monday, confirming Wigglesworth will provide cover for Danny Care as a replacement against Wales.

"Ben will have an examination so we'll know more after that," head coach Eddie Jones said.

"He's unlikely to be available for the Wales game. It's too early to make any sort of prediction, but I'm always optimistic."

No. 8 Sam Simmonds and wing Anthony Watson crossed twice each in a seven-try rout of Italy, whose endeavour was not reflected in the scoreline, and Jones was delighted by their contributions.

"Sam's a good, young lad with a great set of skills. If he was a cricketer he'd be playing Twenty20. He's a bit different -- he's fast and runs good lines," Jones said.

"He's a completely humble boy who just gets on with it. He's fitted into the team well. He's different to Billy Vunipola and Nathan Hughes and sometimes it takes sides a bit of time to adjust to that, but our adjustment was good. At the end of the game we played some lovely rugby.

"Watson got the Maserati out of the car park. He's got great pace. You look at him and Jonny May on the wing, we've got close to probably the quickest wingers in the world. And they're only going to get quicker."