Wade has battled migraines at various times during his career and in January missed a game because of symptoms. That bout left him with light sensitivity for several days. He used tinted goggles in a game at New York but still scored 34 points in a loss to the Knicks.
The headache started to bother Wade before Saturday's Game 1, a 97-89 Miami victory, in which Wade finished with just 17 points and battled rare foul trouble.
"We're trying to be proactive," Heat coach Erik Spoelstra said. "He's had them before so we'll see how he feels at the end of the day. He's getting some rest and taking some medicine and we're going from there."
Despite the migraine problems, Wade's teammates are confident he'll play Monday.
"I called him this morning and he didn't answer," LeBron James said. "We expect him to be here tomorrow. We'll give him a full day today and a full day tomorrow and he'll be here."
Brian Windhorst covers the Heat for ESPN.com.