Colgate (7-1, 7-1 Patriot League) led 36-32 at halftime, and after Austin Butler's layup with 8:05 remaining brought the Crusaders within 58-50, Colgate went on a 14-4 run to put it out of reach.
Jeff Woodward added 10 points for Colgate, which now has won six straight, the last four of which have come against the Crusaders.
Colgate's average margin of victory has been 19 points against Holy Cross.
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