Both players combined in the buildup for the opening goal after 11 minutes. Ndombele produced a stunning backheel to keep the ball in play which Kane knocked on to Moura, and his cross was turned into his own net by Bade.
Rennes started to dominate after the goal and grabbed a deserved equaliser after 23 minutes when Tait curled the ball into the bottom corner from outside the box.
Hojbjerg replaced the injured Bergwijn just after the half an hour mark but Spurs' play didn't improve and were lucky to finish the half at 1-1.
Moura picked up a knock during the early stages of the second half after a heavy challenge and was replaced moments later.
Rennes took the lead after 72 minutes when Laborde was the quickest to react to Pierluigi Gollini's save to tap home.
Spurs levelled five minutes later when Hojbjerg collected Matt Doherty's deflected cross to score from close range.
When asked about the injuries after the game, Nuno said: "It's been terrible, I must be honest. Let's not hide behind anything.
"After the Watford game, everything that has happened has not been very good for us. But this is football. And we know it's a moment we have to overcome."