Uruguay have enjoyed 15 years of success under Oscar Washington Tabarez, but with World Cup qualifying in jeopardy, it may be time to say goodbye.
Brazil's Neymar scored in a 4-1 win that leaves his former Barcelona teammate Luis Suarez and Uruguay with an uphill struggle to make the World Cup.
Raphinha turned in another eye-catching performance for Brazil on Thursday by scoring twice in the home side's 4-1 victory over Uruguay.
Peru missed a penalty in a 1-0 loss to Argentina in Buenos Aires on Thursday, delivering another blow to their hopes of World Cup qualification.
With five South American World Cup qualifiers to be played on Thursday, Europe-based players will be late returning to their clubs this weekend.
Chile are still reliant on old stalwarts like Arturo Vidal and Alexis Sanchez, but England-born Ben Brereton Diaz gives 'La Roja' the best chance.
Neymar's Brazil teammates are hoping he will remain with the national team after next year's World Cup, despite him saying it could be his last.
Neymar said the 2022 World Cup being his last, while it will surely be Lionel Messi's final one. They are entitled to dream of going out on a high.
Brazil star Neymar says next year's World Cup in Qatar could be the last of his career.
Argentina beat Uruguay in World Cup qualifying thanks to goals from Lionel Messi, Rodrigo De Paul, and Lautaro Martinez.
Colombia held Brazil to a 0-0 draw in an engrossing game on Sunday, ending Brazil's nine-match winning run in World Cup qualifiers.
Chile and Bolivia have the chance to get back into World Cup contention with two crucial home games over the next few days.
Brazil fought back from a goal down to score three times in the second half for a 3-1 win over Venezuela.
Argentina failed to score for the first time since June 2019 but a 0-0 draw at Paraguay maintained their unbeaten record in World Cup qualifying.
Brazil are leading the way in CONMEBOL qualifying, but what about the rest as this week's tripleheaders see two-thirds of games complete?
Lionel Messi and Paulo Dybala have been included in the Argentina squad for the upcoming World Cup qualifiers despite injury concerns.
Brazil coach Tite has included eight Premier League-based players for next month's World Cup qualifiers at Venezuela, Colombia and Uruguay.
Premier League clubs which blocked South American players from traveling to World Cup qualifiers will be able to play them this weekend.
Brazil and Argentina each have one foot in Qatar after both won again but the night belonged to Lionel Messi as he broke Pele's longstanding record.
Neymar has said he doesn't get the respect he deserves from the Brazilian media and fans after breaking a new record for the national team.
Everton Ribeiro got his second goal in two games to help Brazil on their way to a 2-0 win over Peru in a World Cup qualifier in Recife on Thursday.
Lionel Messi scored a hat-trick to give Argentina a 3-0 win over Bolivia, moving him above Pele as South America's top male all-time scorer.
Argentina's Lionel Messi has surpassed the record set by Brazil legend Pele for the most international goals scored by a South American man.