Malawi MWI 1 - 0 |  Botswana BOT | FT | Kamuzu Stadium | N/A |
| Malawi lead 1-0 on aggregate |
Eswatini SWZ 0 - 0 |  Djibouti DJI | FT | Mavuso Sports Centre | N/A |
| Djibouti advance 2-1 on aggregate |
Zimbabwe ZIM 3 - 1 |  Somalia SOM | FT | Barbourfields Stadium | N/A |
| Zimbabwe lead 3-2 on aggregate |
Mozambique MOZ 2 - 0 |  Mauritius MRI | FT | Estádio do Zimpeto | N/A |
| Mozambique lead 3-0 on aggregate |
Angola ANG 2 - 1 |  Gambia GAM | FT | Estádio 11 De Novembro | N/A |
| Angola lead 3-1 on aggregate |
Rwanda RWA 7 - 0 |  Seychelles SEY | FT | Stade Régional Nyamirambo | N/A |
| Rwanda lead 10-0 on aggregate |
Togo TOG 2 - 0 |  Comoros Islands COM | FT | Stade de Kégué | N/A |
| Togo lead 3-1 on aggregate |
Guinea-Bissau GNB 2 - 1 |  Sao Tome e Principe SAO | FT | Stade du 24 Septembre | N/A |
| Guinea-Bissau lead 3-1 on aggregate |
Namibia NAM 2 - 0 |  Eritrea ERI | FT | Sam Nujoma Stadium | N/A |
| Namibia lead 4-1 on aggregate |
Sudan SUD 0 - 0 |  Chad CHA | FT | Al-Merreikh Stadium | N/A |
| Sudan lead 3-1 on aggregate |