Alice Davidson-Richards has won a recall to England's ODI squad in the wake of her century on Test debut, while there are maiden call-ups for Issy Wong and Lauren Bell for the 14-woman group to take on South Africa.
Davidson-Richards made her only previous ODI appearance more than four years ago, but impressed in the drawn Test at Taunton, where she scored 107 and took 1 for 43 - making her only the second England player, after WG Grace, with a hundred and a wicket on Test debut.
Wong and Bell both won their first England caps in the Test, and could now make ODI debuts in the three-match series starting on July 11. England have suggested that they will manage the workload of Wong, 20, but the temptation to throw her in will be great after a display of pace and accuracy in Taunton, where she claimed 3 for 100.
Katherine Brunt, who has retired from Test cricket, returns to the group, as does Danni Wyatt. Of the players who featured in England's run to the World Cup final earlier this year, Anya Shrubsole has retired, Tash Farrant is injured and Freya Davies misses out - named instead among a 13-woman England A squad to play a T20 warm-up against South Africa on Monday.
"Although these South Africa ODIs don't form part of the ICC Women's Championship, we are at the beginning of a new three-year cycle, which is so exciting," England head coach, Lisa Keightley, said. "We have to keep looking forward and trying to improve as a team, and we were so delighted with the energy and skill that the four debutants brought in the LV= Insurance Test match.
"I'm looking forward to hopefully seeing something similar in the Royal London Series and throughout the rest of the summer, with new players putting their hands up to win games for England and selection becoming tougher and tougher as more players make a case to be included."
England Women ODI squad: Heather Knight (capt), Tammy Beaumont, Lauren Bell, Katherine Brunt, Kate Cross, Alice Davidson-Richards, Charlie Dean, Sophia Dunkley, Sophie Ecclestone, Amy Jones, Emma Lamb, Nat Sciver, Issy Wong, Danni Wyatt
England Women A Squad: Bryony Smith (capt), Maia Bouchier, Alice Capsey, Kira Chathli, Freya Davies, Dani Gibson, Bess Heath, Marie Kelly, Freya Kemp, Linsey Smith, Mady Villiers. Travelling reserve: Grace Potts