Head coach Jeff Brohm on Thursday confirmed the outlook for O'Connell, who originally injured the foot in the Boilermakers' second game of the season, a 31-24 win over llinois on Oct. 31. O'Connell played in the team's next game Nov. 14 against Northwestern but has missed the past two games.
A junior, he had 916 passing yards with seven touchdowns and two interceptions in Purdue's first three games.
In the past two seasons, O'Connell has completed 63.7% of his passes for 2,017 yards with 15 touchdowns and six interceptions. Like all FBS players, O'Connell will not have this season count against his eligibility.
Sophomore Jack Plummer has started Purdue's past two games, losses to Minnesota and Rutgers, and is expected to start this week against Nebraska at home.
Brohm also said Purdue is dealing with several players who are opting out for the rest of the season.
"It's all personal reasons and there's always a little of this and a little of that to it, so I don't want to get into the specifics," Brohm said. "But yeah, we've had multiple people."