The news comes on the heels of several star players opting out, including Penn State linebacker Micah Parsons, Miami defensive lineman Greg Rousseau, Minnesota receiver Rashod Bateman and Virginia Tech cornerback Caleb Farley.
Moore, a former All-American who missed much of last season with an injury, is No. 32 on Todd McShay's list of top NFL prospects.
Moore announced his decision to opt out via Twitter on Thursday, citing the "unprecedented circumstances we are currently living in."
Farewell 🖤 pic.twitter.com/4LioRRoOEM— Rondale Moore (@moore_rondale) August 6, 2020
Head coach Jeff Brohm thanked Moore in a statement later Thursday.
"From the moment he first took the field, he electrified Ross-Ade Stadium and college football with his record-breaking performances and unique ability," Brohm said. "He always represented our program with class and dignity, and we fully support him and his family as he pursues his professional future. Rondale is a special player and person, and we know he will be a star at the next level and beyond."
The 5-foot-9 Moore caught 114 passes for 1,258 yards and 12 touchdowns as a true freshman in 2018. He also rushed 21 times for 213 yards and two touchdowns, becoming the first true freshman consensus All-American in Big Ten history.