Monday, 8:15 p.m. ET | ESPN
Matchup rating: 82.3 | Spread: TB -3.5 (48)
What to watch for: There has been a scoring discrepancy for the Bucs in prime time versus earlier games this season. They are averaging 15.6 points for and 27 points against in prime-time games, compared to 29.6 for and 22.6 against in the earlier slates. This is their final of four prime-time games this season, and they're 1-2 in those games. To win, they'll need to shut down the run early -- a forte of theirs under defensive coordinator Todd Bowles -- to limit Rams quarterback Jared Goff's play-action opportunities and not get swept up in Los Angeles coach Sean McVay's elaborate use of motion. The Buccaneers also need to give QB Tom Brady ample time to go through his progressions and make deep throws, something he didn't have against the Saints two weeks ago. -- Jenna Laine
Bold prediction: Rams defensive tackle Aaron Donald will record his third multisack game of the season. Sacks come in bunches, and the Rams' defensive front is on a roll, coming off a six-sack performance against Russell Wilson and the Seahawks. However, in two career games facing Brady, Donald has never taken down the three-time NFL MVP. Donald also was held without a sack against the Seahawks, so watch for the two-time NFL Defensive Player of the Year to be extra motivated on Monday. -- Lindsey Thiry
Stat to know: Buccaneers wide receiver Mike Evans has linked up with Brady for seven red zone TD catches this season, second among quarterback-receiver duos in the NFL (Kirk Cousins and Adam Thielen have eight).
What to know for fantasy: Tampa Bay running back Ronald Jones has been a top-25 performer at the position in five of his past seven games and has a touchdown or three catches in seven straight games. See Week 11 rankings.
Betting nugget: Brady is 8-1-1 ATS in his career on Monday Night Football as a favorite of seven points or fewer. Read more.
Thiry's pick: Rams 24, Buccaneers 21
Laine's pick: Buccaneers 30, Rams 26
FPI prediction: TB, 65.3% (by an average of 5.3 points)
Matchup must-reads: Rams' Ramsey: "Time to start talking about" Williams as household name ... Arians: AB "a model citizen" since joining Bucs ... Whitworth heads to IR, but Rams hopeful he can return in 6-8 weeks ... First all-Black NFL officiating crew to work Monday Night Football game ... Jones rewards Bucs for patience with big day, record-setting play