No. 8 seed Vondrousova raced into an early lead after winning the opening set in just 27 minutes, forcing Van Uytvanck to make another incredible comeback.
The No. 1 was also made to fight from a set down in her quarterfinal and semifinal matches and had to save five match points in her semifinal victory over No. 5 seed Ekaterina Alexandrova on Saturday.
She responded by edging a tight second set 7-5 before winning the opening four games of the decider to take a commanding lead.
Van Uytvanck then sealed her victory on serve to secure her third career title in exactly two hours, following victory in Budapest in 2018 and Bienne in 2017.