Allen Clarke's first PRO14 game in charge of the Ospreys ended in a 26-15 defeat to Conference A rivals Connacht at the Sportsground.
Ospreys and Wales hooker Scott Baldwin is set to miss the rest of the season after suffering a foot injury.
Gloucester moved to the top of Pool One in the Anglo-Welsh Cup with a bonus-point 43-20 win over Ospreys at Kingsholm.
Rhys Webb is a major doubt for the Six Nations after being withdrawn from Wales' squad with a knee injury that will "restrict his involvement in the campaign".
Dan Biggar is likely to miss the first three matches of Wales' 2018 Six Nations campaign with a shoulder injury.
Ospreys head coach Steve Tandy has paid the price for poor results as the Welsh region confirmed the former PRO12 winning coach will leave the region with immediate effect as their search for a "world-class" replacement begins.
Clermont are through to the quarter-finals of the Champions Cup as winners of Pool 2 thanks to a 24-7 victory over Ospreys - and bagged a home game in the knock-out stage.
Ireland and British & Irish Lions wing Tommy Bowe has revealed he will bow out of professional rugby at the end of the campaign.
Billy Vunipola provided England with an injury scare as holders Saracens' European Champions Cup quarterfinal hopes were left hanging by a thread.
Wales scrum-half Rhys Webb scored two tries as Ospreys held on to seal a 29-28 bonus-point victory over Cardiff in the Guinness PRO14 at the Liberty Stadium.
Warren Gatland has suffered a potential blow ahead of the 2018 Six Nations, with Wales and Ospreys backrow Dan Lydiate now a major doubt due bicep injury.
The Ospreys ended their PRO14 drought with victory over the Dragons at Rodney Parade as the last rugby match of 2017 in the UK dribbled to a lacklustre conclusion.
A stoppage-time try by replacement Josh Macleod saw 14-man Scarlets edge Ospreys 12-9 in a dramatic Guinness PRO14 derby at a rain-drenched Parc y Scarlets.
Replacement scrum-half Rhys Webb scored twice as Ospreys completed a European Champions Cup double over struggling Northampton with a 32-15 bonus-point victory at a wet Liberty Stadium.
Northampton pushed hard in a second-half fightback but couldn't overcome Ospreys as they fell to a 43-32 Champions Cup defeat at Franklin's Gardens.
Munster's new head coach Johann van Graan enjoyed a winning home debut at Irish Independent Park where the under-strength Ospreys were beaten 36-10.
Wales centre Scott Williams is to leave Scarlets at the end of the season and join their Welsh regional rivals Ospreys.
Fatherhood has changed Alun Wyn Jones. Captain of Wales, nine-time British & Irish Lion, but then he is husband to Anwen and father to Mali, with another on the way.
Wales played their final Test at St Helen's 20 years ago this month. The multipurpose ground is still fondly remembered by those who experienced its unique atmosphere.
Wasps recorded the first win of their Anglo-Welsh Cup campaign on Friday night with a 36-12 victory over the Ospreys at the Liberty Stadium.
Flanker Justin Tipuric and scrum-half Rhys Webb are understood to be major doubts for Wales' autumn series opener against Australia on Saturday.
Twenty points from Jason Tovey saw Richard Cockerill's Edinburgh defeat Ospreys 37-10 in the PRO14 and in doing so recorded a fifth consecutive win in all competitions.
Ospreys wing Keelan Giles faces knee surgery after being hurt while in PRO14 action.
Saracens shrugged off their post-Northampton lethargy to reclaim top place in Pool Two of the Champions Cup by registering a bonus-point 36-34 victory over a spirited Ospreys at Allianz Park.
Ospreys scrum-half Rhys Webb has hit out at the WRU's decision to prevent players with fewer than 60 caps playing abroad from representing Wales.
- OSP5thTRIES SCORED 1st Saracens : 24 Tries ScoredSARAC1st1824
- OSP13thPOINTS DIFFERENCE 1st Leinster : 83 Points DifferenceLEINS1st483