Wasps recorded the first win of their Anglo-Welsh Cup campaign on Friday night with a 36-12 victory over the Ospreys at the Liberty Stadium.
Flanker Justin Tipuric and scrum-half Rhys Webb are understood to be major doubts for Wales' autumn series opener against Australia on Saturday.
Twenty points from Jason Tovey saw Richard Cockerill's Edinburgh defeat Ospreys 37-10 in the PRO14 and in doing so recorded a fifth consecutive win in all competitions.
Ospreys wing Keelan Giles faces knee surgery after being hurt while in PRO14 action.
Saracens shrugged off their post-Northampton lethargy to reclaim top place in Pool Two of the Champions Cup by registering a bonus-point 36-34 victory over a spirited Ospreys at Allianz Park.
Ospreys scrum-half Rhys Webb has hit out at the WRU's decision to prevent players with fewer than 60 caps playing abroad from representing Wales.
European club rugby is back for the second weekend in a row with another stacked fixture list. ESPN's experts predict which teams are set for a big weekend, which players will shine and where your attention should be trained across the two competitions.
Scott Baldwin could make his first Ospreys appearance since being bitten by a lion against Saracens in the Champions Cup Saturday.
In adopting Australia's 60-cap rule the Welsh Rugby Union has used a blunt instrument to solve a problem that required a more subtle approach, writes John Taylor.
Mourad Boudjellal has warned Warren Gatland that Toulon would require a fee to release Rhys Webb from his contract.
Wales hooker Scott Baldwin was told escaping serious injury following an encounter with a lion in South Africa was "like winning the lottery".
The Ospreys staged a second-half fightback to scare French giants Clermont, gaining themselves a losing bonus point
European club rugby returns after a five month absence, and the first round of fixtures should not disappoint.
Wales prop Samson Lee scored his first try in more than 100 appearances for Scarlets to edge the reigning PRO12 champions to victory over arch-rivals Ospreys.
Wales scrum-half Rhys Webb will leave the Ospreys at the end of the current season, it has been confirmed.
Ospreys are confident Scott Baldwin will make a full and speedy recovery from a lion bite but head coach Steve Tandy joked the hooker might only have "four fingers left."
Scott Baldwin has set the bar high in terms of bizarre sporting injuries, but he is by no means alone in his admittedly novel approach to skipping matches.
Ospreys and Wales forward Scott Baldwin suffered a laceration to his hand and missed his side's defeat to the Cheetahs.
The Cheetahs secured their third successive PRO14 victory in Bloemfontein to consign the Ospreys to a fourth straight defeat.
Scarlets survived a real scare from Connacht to seal a a bonus-point 36-27 victory in a nine-try thriller in Llanelli.
Braam Steyn crossed inside two minutes as Benetton Treviso made it back-to-back Guinness PRO14 wins with a 16-6 victory over struggling Ospreys at Stadio Comunale di Monigo.
Munster held off a second-half comeback from Ospreys to register their third straight Guinness PRO14 victory in torrential rain at the Liberty Stadium.
Glasgow made it two wins from two with a 31-10 success against Ospreys as new coach Dave Rennie enjoyed a positive first home match at the helm.
Ospreys claimed their first win in Conference A of the expanded Guinness PRO14, but it was far from convincing against Zebre at the Liberty Stadium.
Bath back row Guy Mercer has joined the Ospreys on loan until the end of the season.
- OSP5thTRIES SCORED 1st Saracens : 13 Tries ScoredSARAC1st713
- OSP13thPOINTS DIFFERENCE 1st Saracens : 46 Points DifferenceSARAC1st-746