Connacht booked their place in the quarterfinals of the Challenge Cup after a 24-24 draw with Worcester.
Former France half-back Frederic Michalak will retire from rugby at the end of the season.
Sale drew at home to Toulouse last week but were beaten at the death by Frederic Michalak's penalty in Lyon.
Cardiff got their campaign up and running with a bonus-point victory over Top 14 leaders Lyon, the Welsh outfit emerging 29-19 victors at Cardiff Arms Park.
European club rugby returns after a five month absence, and the first round of fixtures should not disappoint.
Anthony Tuitavake was sent off as Racing 92 lost 23-19 at Agen in the Top 14.
Carl Fearns is targeting a place in the France squad after being told by Eddie Jones that he would not last 15 minutes in a Test match.
With Top 14 rugby kicking off on Saturday, we look at every club in France's elite division and try to predict where they will end up next June.
Top 14 side Lyon have secured the signature of former Wallabies flanker Liam Gill after he spent a season in France with Toulon.
The final day of the Top 14 sees Clermont battling with Montpellier for a semifinal spot and a point separates Racing 92 (6th), Stade Francais (7th) and Pau (8th) for the last Champions Cup spot.
Brock James and La Rochelle survived a late scare to defeat Montpellier 40-37 as they secured top spot in the Top 14 and can now prepare for a home semifinal.
Gloucester have rubbished reports in the French media that Carl Fearns will be staying in the Top 14, stating reports suggesting otherwise were "unfounded".
La Rochelle maintained control of the Top 14 with a 23-13 victory over Pau which stretch their lead to 10 points at the summit of the Top 14.
La Rochelle are out to an eight point lead in the Top 14 standings after Clermont fell to Montpellier on Sunday.
Pau have won five matches in a row in the Top 14 after a convincing 38-15 triumph over Lyon.
French Top 14 club Lyon reportedly sounded out England rugby legend Jonny Wilkinson over a potential short-term move.
Toulon's climb up the Top 14 table was arrested by Castres Olympique on Saturday afternoon, as the home team prevailed 34-19 at the Stade Jean-Pierre Antoine. F
A Ben Botica penalty three minutes into stoppage time saw Montpellier record a 12-11 victory over La Rochelle.
Edinburgh got their Challenge Cup campaign off to a perfect start with a 59-17 win over Romanian side Timisoara Saracens.
Stade Francais edged past Castres 29-25 in an action-packed match at Stad Jean-Bounin.
- LYON7thTRIES SCORED 1st La Rochelle : 55 Tries ScoredLA RO1st3955
- LYON6thPOINTS DIFFERENCE 1st La Rochelle : 157 Points DifferenceLA RO1st39157