Eddie Jones has named his England side to face South Africa in the final of three Tests in Cape Town on June 23.
Danny Cipriani will make his first start for England since 2008, replacing George Ford at fly-half.
The England head coach made three other changes to the starting XV, with Joe Marler named in the front row replacing Mako Vunipola, who returned home earlier in the week for family reasons.
At blindside flanker, Chris Robshaw replaces Brad Shields due to illness and Nathan Hughes starts in place of Billy Vunipola following his injury last weekend.
In a statement on the England Rugby website, Jones said: "We've had a really upbeat training week.
"We are up for the battle and are going to rip in on Saturday. We want another committed performance where it will be crucial to maintain our composure when the heat is on."
England head into the final Test against South Africa at a 0-2 deficit.