Eddie Jones has made one change to his side for England's Calcutta Cup clash with Scotland as Nathan Hughes returns at No. 8.
The Wasps forward missed the opening two games with a knee injury, but returns to the matchday 23-man squad alongside prop Joe Marler, who is named on the replacements' bench.
Lock Joe Launchbury will win his 50th cap at Murrayfield, while captain Dylan Hartley will become England's second-most capped player of all time as he earns a 92nd.
"We are really excited about this game and we will need to be very tough and relentless in our defence to keep the pressure on this Scottish team," Jones said.
"They are renowned for their attack so we will need to put pressure on them, create opportunities through our defence for our attack, and convert those opportunities to points.
"Our preparation over the last two weeks has been important in that it has allowed us to regenerate the players, improve the fitness of some and to get a clear understanding on how we will play this weekend.
"Nathan Hughes has worked hard on his fitness. I've never seen him in better physical condition so we are looking forward to him playing. Nathan has a key role in defence and in us gaining momentum in attack."
England squad to play Scotland:
Brown, Watson, Joseph, Farrell, May, Ford, Care; M. Vunipola, Hartley (captain), Cole, Launchbury, Itoje, Lawes, Robshaw, Hughes.
Replacements: George, Marler, Williams, Kruis, Underhill, Wigglesworth, Te'o, Nowell.