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Leigh Halfpenny ruled out for Wales against England

Leigh Halfpenny has been ruled out of Wales' clash with England. Nigel French/PA Images via Getty Images

Leigh Halfpenny has been ruled out of Wales' Six Nations clash with England at Twickenham.

As revealed by ESPN, Halfpenny was unable to take part in Friday's captain's run and has now been ruled out of the game.

It is a huge blow to Welsh chances after Halfpenny scored all but 10 of his side's 34 points last week in their victory over Scotland.

Cardiff Blues' Gareth Anscombe makes the step up from the bench with Owen Watkin taking his place among the replacements at Twickenham.