Wasps fly-half Danny Cipriani is set to miss up to 12 weeks of action after sustaining a medial ligament tear in his knee, the club have announced.
The 29-year-old suffered the injury during his side's 21-24 defeat by Harlequins on Sunday and is not expected to return until the end of November at the earliest, having consulted a specialist on Tuesday.
There was worse news for Wasps teammate Alex Rieder, who will be out of action for around four months due to requiring an operation after he dislocated his shoulder in the same game.
James Gaskell is set to miss three-to-four weeks with a hamstring injury, while fellow second-rower Kearnan Myall faces 8-10 weeks on the sidelines thanks to an ankle injury. Wasps also confirmed that Guy Thompson (dead leg) is expected back in training within a week while Dan Robson (knee) is "hoped to return in the next couple of weeks".
"It's obviously not ideal to be without some of our key players but it's likely to happen to a number of clubs at some stage during the season," said the club's director of rugby, Dai Young.
"Unfortunately, we've picked up a few injuries early doors, which is obviously going to stretch us, but we just need to deal with that. We have a strong squad and that's what building quality throughout the squad is for.
"You feel for the players who have picked up injuries, particularly those who look like they will be out for a few weeks when they've been playing well in the opening part of the season. They will be working hard with our physios to make sure they rehab in the best way possible to come back in good shape as soon as they are ready."