Juan Martin Hernandez has replaced ankle-injury victim Nicolas Sanchez at fly-half for Argentina's clash with England at Twickenham on Saturday.
In total there are three changes to the side defeated by a last-minute penalty against Scotland last weekend, among them a new half-back pairing that sees Tomas Cubelli replace Martin Landajo to link up with Hernandez.
Hernandez, a survivor from the Pumas' 25-18 triumph at Twickenham in 2006, moves from inside centre so Santiago Gonzalez Iglesias is elevated into the number 12 jersey. Completing the changes is Leonardo Senatore's promotion to the back row in place of Facundo Isa.
Head coach Daniel Hourcade said: "Having Hernandez in the starting line-up is always a benefit for the team and of course playing at 10 is a position that he prefers. "It is not only Hernandez's experience of that game which is important, it is his knowledge, his experience in many situations that is important for the team."
Argentina team to face England:
Tuculet, Orlando, Moroni, Iglesias, Cordero, Hernandez, Cubelli; Noguera, Creevy, Herrara, Petti, Alemanno, Matera, Desio, Senatore.
Replacements Montoya, Bottai, Pileretto, Isa, Lezana, Landajo, De La Fuente, Estelles.