South Africa coach Allister Coetzee has made seven changes to his side as the Springboks bid to end a disappointing tour on a high against Wales.
Coetzee's squad head to Cardiff on the back of a first ever defeat to Italy, and the coach has reacted by handing out three debuts for their final clash of 2016.
Flanker Uzair Cassiem is joined in the starting XV by wing Jamba Ulengo and centre Rohan Janse van Rensburg. Jean Luc du Preez could win his first cap from the bench.
The changes mean that there is no place in the 23-man squad for a host of senior players, including Willie le Roux, JP Pietersen and Bryan Habana.
Asked about 33-year-old Habana's immediate Test future at a press conference in Cardiff, Coetzee said: "I would not go as far as saying it is the end for him.
"He has not just got a role to play on the field, but a massive role off it for South African rugby. What he has been doing this week is mentor Jamba Ulengo and share his knowledge and experience.
"I sat with him [Habana] at the beginning of the season and talked about the role I wanted him to play in the Rugby Championship and the European tour. Obviously, we now have to review that."
Fly-half Pat Lambie, meanwhile, has been dropped to the bench with Elton Jantjies taking over at 10.
South Africa team to play Wales:
Goosen, Combrinck, Venter, van Rensburg, Ulengo, Jantjies, de Klerk; Mtawarira, Strauss, Adriaanse, du Toit, de Jager, Carr, Cassiem, Whiteley.
Replacements: Marx, Kitshoff, Nyakane, Mostert, du Preez, van Zyl, Lambie, Mapoe.