Leicester Tigers will be without fly-half Owen Williams for eight weeks with the club confirming he suffered a double fracture of the jaw against Northampton at the weekend.
Williams was forced off after 32 minutes and was replaced by Freddie Burns.
"Owen has had surgery and the injury is obviously very disappointing for him and for us because he has been playing well," said Tigers director of rugby Cockerill. "It's unfortunate for Owen, but we have Freddie Burns and Tommy Bell available at fly-half and they've been playing well too."
Brendon O'Connor was withdrawn from the Northampton match in the opening minutes with a hamstring injury and he is likely to be out of action for several weeks. The Tigers add that Leonardo Ghiraldini, Greg Bateman, Miles Benjamin and Jean de Villiers are continuing to make progress in their return from injury.
Club captain Ed Slater is also sidelined after suffering a knee injury in the defeat at Saracens two weeks ago and Mike Williams is recovering from a broken arm suffered in the win at his former club Worcester in December.