England will be without Billy Vunipola for the autumn internationals after he fractured his arm in Saracens' win over Glasgow Warriors at the weekend.
Billy and Mako Vunipola both went off injured in Saracens' victory over Glasgow on Sunday, putting their participation in England's Autumn internationals in doubt.
Brian O'Driscoll has tipped Exeter Chiefs as favourites to win the Champions Cup title this season, alongside recent winners Leinster and Saracens.
Ulster confirmed their place in next season's Champions Cup with a 35-17 victory over Ospreys at the Kingspan Stadium.
Pat Lambie is almost certain to miss the Springboks' Tests against England after sustaining what is believed to be an anterior cruciate ligament injury in the European Rugby Champions Cup final.
Rugby union displayed its best side in Bilbao over the weekend, as a 61-point thriller of a Challenge Cup final was followed by a tense, nerve-shredding Champions Cup showpiece.