England lock Maro Itoje has been left out of the squad for Saturday's crunch Six Nations match away to Wales after failing to recover in time from a knee injury.
Iain Henderson has been added to Ireland's Six Nations squad while Robbie Henshaw has extended his contract with the IRFU until 2022.
Scotland fly-half Finn Russell is out of Saturday's Six Nations match against France after he failed a concussion test while playing for French side Racing 92.
Romain Ntamack will start at fly-half for France against Scotland on Saturday after Jacques Brunel named five changes to his side in a bid to save their ailing Six Nations campaign.
Finn Russell is a major doubt for Scotland's Six Nations clash with France on Saturday after he suffered a head injury playing for club side Racing 92.
England will be without Chris Ashton for their Six Nations clash against Wales on Saturday due to a minor calf injury, the RFU said on Sunday.