It was unclear when Johnson was hurt, but he was quickly declared out.
Johnson was replaced by a combination of Jordan Willis and rookie Sam Hubbard, who rotated into the Bengals' lineup at defensive tackle and defensive end. Although Johnson has been a longtime starter at defensive end for Cincinnati, the Bengals began moving him inside at times on third down.
Johnson has been with the Bengals since 2009 with the exemption of the 2014 season, which he spent in Tampa Bay. He was initially released during the cut to 53 players but quickly re-signed and voted a team captain 24 hours later.
Center Billy Price also left the game in the first half and walked to the locker room after athletic trainers examined his ankle. He was declared out of the game to start the second half.
Price was on the sideline in street clothes and wearing a walking boot in the third quarter.