Texas Southern (1-13) won its first game of the season in a Southwestern Athletic Conference opener for both teams.
Bruce made a career-best eight 3s on 12 attempts and Jefferson was 5 of 11 as Texas Southern made 15 of 38 from 3-point range. Jefferson reached 20-plus points for the 10th time this season.
Texas Southern went on a 17-5 run -- with three 3-pointers from Bruce -- midway through the first half for a 27-13 lead. But Southern closed the half by scoring the final six points to pull within 37-34.
Southern was within 52-48 with 13:37 to go but didn't make its next field goal until the 8:21 mark and trailed 66-51.
No. 8 Villanova set for title rematch vs. No. 18 Michigan
Villanova will face its toughest test yet this season when it hosts No. 18 Michigan Wednesday night at Finneran Pavilion as part of the Gavitt Tipoff Games.
Bichi Fuertes: 'Vengo a dar una mano'
El nuevo DT de Colón asume en reemplazo de Eduardo Domínguez.
Georgia's plane slides off runway, delaying trip to Philly until Tuesday
The start of Georgia's road trip to Philadelphia to play Temple was delayed until Tuesday morning after the team's plane slid off the runway Monday night.