Hamilton went 5 of 9 from 3-point range and 7 of 11 overall and made all six of his free throws. Blackston was 10 of 11 from the field. Iwin Ellis and J.D. Wallace had 10 points apiece for the Panthers (3-11) and Dennis Jones had eight points and 10 assists.
Prairie View A&M shot 70 percent (21 of 30) in the first half with eight 3-pointers. Hamilton had 22 points and Blackston 18 as the Panthers opened a 59-32 lead over the Bulldogs, who shot 52 percent.
The lead reached 40 less than five minutes into the second half. All 11 players scored for the Panthers.
Isaiah Lopez had 12 points for Jarvis Christian.
Kansas State heads to West Virginia with Wade ailing
The word of the day will be "short-handed" when No. 18 Kansas State and West Virginia face off Monday in a Big 12 game in Morgantown, W.Va.
Williams throws down one-handed hammer
Cincinnati's Keith Williams finishes a fast break with a vicious jam.
Winston drops dime to Goins for the jam
Cassius Winston throws the perfect bounce pass to Kenny Goins, who finishes with authority.