Mayo scored the Colonels' first six points, and his third jump shot gave Eastern Kentucky a 6-5 lead it never gave up. EKU then went on a 17-7 run with Dujuanta Weaver, Peyton Broughton and Dillon Avare each burying 3-pointers.
DeAndre Dishman and Avare each scored 12 points and Broughton added 10 for Eastern Kentucky (6-6). The Colonels led 41-30 at halftime and extended the margin to 62-35 on Broughton's jumper with 11:23 left to play.
The Colonels were 29-of-55 shooting (53 percent) and made 10 3s. Eastern Kentucky had a 33-23 rebounding advantage.
No. 8 Villanova set for title rematch vs. No. 18 Michigan
Villanova will face its toughest test yet this season when it hosts No. 18 Michigan Wednesday night at Finneran Pavilion as part of the Gavitt Tipoff Games.
Bichi Fuertes: 'Vengo a dar una mano'
El nuevo DT de Colón asume en reemplazo de Eduardo Domínguez.
Georgia's plane slides off runway, delaying trip to Philly until Tuesday
The start of Georgia's road trip to Philadelphia to play Temple was delayed until Tuesday morning after the team's plane slid off the runway Monday night.