Elijah Minnie hit a 3-pointer from the right corner with 1:17 left to make it 53-47 and finished an alley-oop off Jackson's assist to extend the lead to eight with 48 seconds to go.
The Eagles (12-9, 3-5 Mid-American Conference) trailed 30-29 at halftime and took control early in the second with 13 straight points to lead 42-32.
The RedHawks (11-10, 4-4) closed within 45-43 after Nike Sibande and Dalonte Brown hit back-to-back 3s to cap an 11-3 run and trailed 50-47 with 1:39 left before Minnie's late baskets helped Eastern Michigan pull away.
Minnie added 12 points for the Eagles.
Brown had 17 points and Sibande scored 10 for the RedHawks.
Highlights: Columbia 74, Iona 71 - Via Ivy League
Highlights from Columbia's 74-71 win over Iona at Madison Square Garden
Texas snaps 3-game skid against Purdue 72-68
Matt Coleman III scored 22 points and delivered the big second-half counterpunches Texas needed to overcome a career effort from Purdue's Carsen Edwards as the Longhorns snapped a three-game losing streak with a 72-68 victory Sunday.
Haliburton's 17 assists lead Iowa State past Southern 101-65
Freshman Tyrese Haliburton set a new Iowa State record with 17 assists, Marial Shayok had 20 of his 26 points in the second half and the Cyclones cruised past Southern 101-65 on Sunday.