Brandon Cyrus scored 12 and Austin Grandstaff had 11 for the Blue Demons (6-4), who won their fifth straight while keeping the Bulldogs (0-9) winless. DePaul has its longest streak since winning seven straight in the 2012-13 season.
DePaul opened the game with a 25-5 run and led by 29 before going into halftime up 48-22. The Blue Demons kept the lead above 20 except once when the Bulldogs made it 53-34 early in the period.
DePaul had its largest lead at 76-45 on McCallum's 3-pointer with 5:32 to go.
Miami's Dewan Hernandez still hopes to play after ruling again upheld
An NCAA legislative committee upheld on Monday two previous decisions regarding potential rules violations involving Miami junior Dewan Hernandez, who has been held out of competition since the start of the season.
No. 18 Ole Miss tests new ranking against LSU
Ole Miss, picked 14th in its conference back in October, is now ranked 18th in the country.
Sold-out arena awaits No. 12 Kentucky at Georgia
No. 12 Kentucky looks to continue its climb back to the top when the Wildcats travel to Georgia on Tuesday night.