Thybulle scored 24 of his career-high 26 points in the second half and Noah Dickerson added 14 as Washington snapped a three-game losing skid by pulling away for an 82-59 victory over Colorado in a Pac-12 Conference game on Saturday night.
Thomas, a two-time NBA all-star now with the Los Angeles Lakers, had his No. 2 jersey retired at halftime.
"One of our main focuses coming in to this game was to share the ball and just keep the ball moving," Thybulle said. "I've said it before, but today was my day. They left me open and my teammates, they just did a great job of finding me and it just happened to go in."
Dominic Green, making his first start of the season, and Jaylen Nowell each added 11 points for the Huskies (18-9, 8-6). Tyler Bey scored 11 points and McKinley Wright IV had 10 for Colorado (15-12, 7-8).
Washington forced 18 turnovers, converting them into 26 points. The Huskies also had a 17-2 advantage in fastbreak points.
"That was one of the best transition games that we've had all year," Washington coach Mike Hopkins said. "We were able to capitalize, get down, get some easy baskets, get the crowd into the game, get the flow going."
Washington, which let an eight-point halftime lead evaporate in a 70-58 home court loss to Utah on Thursday, maintained its second-half composure against the Buffaloes.
The Huskies led 39-34 at the break and then outscored Colorado 21-6 to open the second half. Two free throws by Thybulle capped a 14-0 run and put Washington up 60-40 with 11:56 remaining.
The Buffaloes pulled within 66-50, but Thybulle sandwiched a pair of 3-pointers around a steal and breakaway dunk to extend the advantage to 74-52 with 4:16 remaining.
"We kept turning the ball over and that's something that doesn't work in basketball," Bey said. "You can't keep turning the ball over and expect to win. We'll get back to work and get back to the drawing board."
Thybulle, a 6-5 junior guard from nearby Issaquah, Washington, made 8 of 11 shots, including 4 of 5 from beyond the arc, and was 6 of 6 from the free-throw line. His previous career high was 20 against Yale last season. Thybulle also had four steals, pushing his Washington single-season record to 82 with four regular-season games remaining.
Washington: The Huskies appeared headed toward an NCAA Tournament berth after consecutive home victories over ranked Arizona State and Arizona. Three consecutive losses that followed have them back on the bubble. Their final two regular season games are at home, where they are 14-3.
Colorado: The Buffaloes had won three straight before a costly loss on Thursday at last-place Washington State. Next up are USC and UCLA at home, where Colorado is 11-2. The Buffs finish the regular season at Utah.
THOMAS' JERSEY RETIRED
Former Washington standout Isaiah Thomas, now a member of the Los Angeles Lakers, had his No. 2 jersey retired at halftime. Thomas becomes the third UW player to have his number retired, joining Bob Houbregs (No. 25) and Brandon Roy (No. 3).
"Words can't describe how grateful I am to be standing in front of you guys today," Thomas, a Tacoma native, said during the halftime ceremony. "Getting my jersey retired is more than what I dreamed of as a kid. Knowing my name will last her forever really means the world to me."
Former Washington players Markelle Fultz, the No. 1 overall pick in the NBA in 2017, and Marquese Criss, the No. 8 pick in 2016, were in attendance, as was former coach Lorenzo Romar.
"He relates to every kid in the United States of America," Washington coach Mike Hopkins said of Thomas, a 5-9 point guard and two-time NBA all-star. "He was a guy that people questioned when he went pro. He was the last pick. You look back at his career, he struggled and he became an all-star. He became one of the leading scorers in the NBA. In the NBA! I don't think there's a greater role model or inspiration than Isaiah Thomas."
Washington is at Stanford on Thursday.
Colorado hosts USC on Wednesday.
More AP college basketball: http://collegebasketball.ap.org
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