Barcelona forward Luis Suarez is the leading light in the 20-man Uruguay squad to face Mexico in an international friendly in Houston on Sept. 7.
One of the country's main stars, Paris Saint-Germain striker Edinson Cavani, is being rested after only recently returning to full fitness following a hamstring injury sustained at the World Cup.
Interim coach Fabian Coito has 18 foreign-based players, including Arsenal midfielder Lucas Torreira, with Penarol pair Guillermo Varela and Cristian Rodriguez playing domestically.
Cavani missed PSG's opening two league games but started and scored in a 3-1 win over Angers last weekend.
Also rested for next month's game in the United States is Celta Vigo striker Maxi Gomez, who recently recovered from a knee ligament sprain he sustained at the World Cup.
Uruguay reached the quarterfinals of the World Cup before losing 2-0 to France under long-time coach Oscar Tabarez, who has yet to renew his contract with the country's federation (AUF) which expired after the tournament in Russia.
Under-20 national team coach Coito was chosen to temporarily guide the Celeste in place of the 71-year-old Tabarez.
"The aim was to give continuity to the work that has been done in the senior side," Coito said in a news conference. "To guide the national team is a beautiful responsibility.
"The idea is for everything to go as best as it can as Uruguay is a prestigious team and we have to ensure it remains that way."
Fernando Muslera (Galatasaray), Martín Campana (Independiente); Diego Godin (Atletico de Madrid), Sebastian Coates (Sporting Lisbon), Jose Maria Gimenez (Atletico de Madrid), Gaston Silva (Independiente), Martin Caceres, Guillermo Varela (Peñarol); Diego Laxalt (Milan), Nahitan Nandez (Boca Juniors) Lucas Torreira (Arsenal) Matias Vecino (Inter), Rodrigo Bentancur (Juventus), Carlos Sanchez (Santos) Cristian Rodriguez (Peñarol), Giorgian de Arrascaeta (Cruzeiro), Jonathan Urretaviscaya (Monterrey), Gaston Pereiro (PSV Eindhoven); Cristhian Stuani (Girona) and Luis Suarez (Barcelona).