Second-half goals from Pablo Sarabia and Wissam Ben Yedder put Sevilla in a commanding position against Barca, with Messi left out of the squad.
2018 SeasonAll times ET
Barcelona's Copa del Rey defence is in peril after Malcom, Philippe Coutinho and Clement Lenglet all struggled mightily in a 2-0 defeat at Sevilla.
Sevilla produced a brilliant second-half display to beat Barcelona 2-0 in their Copa del Rey quarterfinal, first leg on Wednesday.
Frenkie de Jong had been a target for a number of top clubs across Europe such as Paris Saint-Germain, Manchester City and Bayern Munich.
Denis Suarez looks set to remain at Barcelona until the end of the season after talks over a move to Arsenal broke down, sources told ESPN FC.
Barcelona signed Kevin Prince Boateng from Italian side Sassuolo on an initial six-month loan with n option to make the deal permanent for €8m.
Barcelona's ethos comes naturally to Philippe Coutinho, but instead of simple tiki-taka football, too often he's trying to be Lionel Messi 2.0.
Barcelona have signed Sassuolo's Kevin-Prince Boateng on loan until the end of the season, the club announced on Monday.
Senegal international Moussa Wague was sent off in the second half after tangling with a home fan as he tried to get the ball back for a throw-in.
Lionel Messi went top of the scoring chart in Europe's top five leagues and Ole Gunnar Solskjaer won his sixth match in a row.
Carlos Vela has told ESPN that he is "happy" at LAFC, but refused to expand on whether he could be headed to Barcelona.
Ousmane Dembele opened the scoring against Leganes and produced one his best performances in a Barca shirt before being forced off injured.
Ousmane Dembele scored one, could have scored more and should have had several assists if not for some sloppy finishing in Barca's win vs. Leganes.
Lionel Messi came off the bench to inspire Barcelona to a 3-1 win over a dogged Leganes side on Sunday, creating one goal and scoring another.
Chelsea have joined Manchester United in the race to sign Philippe Coutinho, who is reportedly unsettled at Barcelona. Transfer Talk has the latest.
A Barcelona delegation went to Amsterdam this week in an attempt to persuade Ajax midfielder Frenkie de Jong to sign, sources have told ESPN FC.