ESPN selects the pick of the Afcon group-stage clashes, for various diverse reasons, following Friday's draw in Cairo.
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At the 2019 Afcon draw, big guns like Egypt and Nigeria got groups some would consider easy, while Group D are the traditional 'Group of Death'.
Some of the continent's less-heralded sides have made the most of the Africa Cup of Nations' expanded format.
Percy Tau scored twice in the second half to seal South Africa's place in the finals, with Libya, who needed to win to qualify, coming up short.
Ahead of the final round of Africa Cup of Nations qualifiers, 14 teams have already qualified, and South Africa should really be among them.
Here's the state of play heading into the final round of Africa Cup of Nations qualifiers, with 10 of the 24 berths in the finals up for grabs.
The final round of Africa Cup of Nations qualifiers runs from 22 to 24 March. Which teams have opted to rest some of their biggest stars?
South Africa are second in Group E, two points ahead of Libya, and need only to draw the fixture in Sfax, Tunisia, to secure AFCON qualification.
The Houston Dash have waived the rights to two South African players, Thembi Kgatlana and Linda Motlhalo, the NWSL side announced on Tuesday.
Cape Town City FC coach Benni McCarthy has all but accused Kaizer Chiefs of trying to hurt his players in their midweek Absa Premiership clash.
New Kaizer Chiefs signing Reeve Frosler says he is looking forward to playing for a club big as Amakhosi, and is keen to win trophies for the club.
South African Premiership club Maritzburg United have announced the appointment of former Bafana Bafana star Eric Tinkler as their new manager.
South African legend Phil Masinga has passed away from "a cancer related disease," the nation's football association has announced.
Nigeria needed penalties to claim the 2018 Africa Women Cup of Nations championship over South Africa, after the match ended 0-0 on Saturday.
South Africa may be celebrating a first-ever FIFA Women's World Cup qualification, but they have their eyes very much on the AWCON title.
As Nigeria prepare for Saturday's final against South Africa, ESPN explore the Super Falcons' evolution during the Africa Women Cup of Nations.
South Africa head coach Des Ellis says her team prepared with all their might to face Mali, rather than risk missing out on the Women's World Cup.
South Africa ended years of heartbreak with a 2-0 Africa Women Cup of Nations semi-final victory over Mali to qualify for the World Cup.
Siyabonga Nomvethe scored just five days short of his 41st birthday to hand bottom side AmaZulu a 2-1 success over Highlands Park on Tuesday.
Baroka FC caused a major upset with a 1-0 Telkom Knockout semi-final victory over defending champions Bidvest Wits on Sunday.
Desiree Ellis has called on her players to provide a "super phenomenal" effort in their African Women's Championship semifinal against Mali.
How did the Chiefs and Pirates players fare in Saturday's Soweto Derby?
Justin Shonga scored a late winner as Orlando Pirates advanced to the final of the Telkom Knockout with a deserved 2-1 victory over Kaizer Chiefs.
Sweden's World Cup-bound national women's team will face Banyana Banyana in an international friendly in Cape Town in January.
Despite a strong start to the Africa Women Cup of Nations, the South Africa coach is keeping her feet grounded.