Hirving Lozano was due to meet the squad in Cordoba ahead of Friday's first match against Argentina, but will miss both matches for Mexico.
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Cruz Azul manager Pedro Caixinha said he has no interest in coaching the Mexico national team, saying he's focused on the Liga MX club.
With two friendlies against Argentina, the exclusion of Javier Hernandez and other veterans from Mexico's squad is an issue that won't disappear.
Hector Herrera and "Tecatito" Corona both had stellar midweek European matches, but which other Mexico internationals had bright European midweeks?
Among the players back for Mexico are Guillermo Ochoa and Hirving Lozano, but Javier "Chicharito" Hernandez and Andres Guardado are left off.
The LA Galaxy and Dennis te Kloese are in talks over becoming the head of the team's of soccer operations, sources have confirmed to ESPN FC.
Quique Sanchez Flores, 53, has previously managed clubs including Benfica, Atletico Madrid and Watford.
Mexico international Hirving "Chucky" Lozano was linked with Manchester United before joining PSV Eindhoven in 2016.
Giovani dos Santos isn't thinking of leaving but rather on improving on his poor 2018, according to the Mexico international's brother and teammate.
"In all the stages [of my career] I've had thoughts about not going, of course," said Hernandez, when asked about playing for Mexico again.
Mexico-born strikers have struggled in Liga MX, which is why this weekend's games benefited the national team ahead of the international break.
In a weekend in which Mexico City took in a derby, Victor Guzman's four-goal performance was the top talking point in Liga MX action.
The Liga MX scoring leader from Argentina said he is preparing his paperwork to become a Mexican citizen and potentially play for El Tri.
Jesus Corona was once Mexico's brightest talent and remains a player capable of the spectacular. Is he finally ready to take that step to stardom?
A report on Tuesday suggested that the FMF had already sounded out the Spaniard for El Tri.
Liga MX is as wide open at the top as it has been in years and that has Tom Marshall asking one question: Why not Cruz Azul?
Cruz Azul have been one of Mexico's "big four" in name only the past decade. Wednesday's Copa MX win changed that and La Maquina might not be done.
Landon Donovan said he believes a potential North American league that features teams from the U.S. and Mexico would be beneficial.
The Atlanta United manager said he did not hear from anyone at U.S. Soccer on whether he'd be interested in taking over as national team boss.
The decision will put the South American tournament in line with UEFA's European Championship.
Hirving Lozano, Hector Herrera, and Jesus Corona made it historic night for Mexican players as each scored in their Champions League game this week.
With Gerardo Martino reportedly set to take over Mexico, the Argentine will need to use next year's Gold Cup to show what he is capable of doing.
Atlanta United announced that coach Tata Martino won't be returning next year, opening the door for the Argentine to manage Mexico or Argentina.
Terms have been agreed to, though no contract has been signed yet due to restrictions on Martino's ongoing deal with Atlanta.
El Tri has emerged from October's friendlies with a number of lessons learnt. With a focus on those two matches, here is the latest Mexico hot-list: