Aston Villa came from behind to knock Manchester City out of the Capital One Cup in extra-time on Tuesday, as Everton succumbed against Leeds and a rampant Chelsea demolished Wolves.
West Ham were the other Premier League side to lose, succumbing 4-1 to Wigan in front of their own fans. Elsewhere, there were wins for Premier League sides Swansea, Sunderland and Southampton against lower league opposition.
Aston Villa shocked Manchester City 4-2 at Eastlands to move into the fourth round of the Capital One Cup.
Mario Balotelli put the Premier League champions into the lead on 27 minutes with his first goal of the season, but Villa were level just before the hour when their former player, Gareth Barry put through his own net.
City fans only had to wait five minutes to get back into the lead, as Aleksandar Kolarov scored with a free-kick. Villa were soon on equal terms as Gabriel Agbonlahor netted his first goal since January to send the tie into extra-time.
Despite heavy City pressure it was Villa who found a way through, Charles N'Zogbia and another from Agbonlahor sending the Villans home victorious.
Leeds claimed a significant scalp as they held off late pressure from Everton to move into the fourth round with a 2-1 victory at Elland Road.
Neil Warnock's side made an ideal start to the game with a fine individual effort by Aidan White, the midfielder weaving his way through the visiting defence before unleashing a fierce drive into the net in just the fourth minute.
David Moyes could have been critical of his side's defending for that goal but would have been even less impressed as the hosts doubled their lead with 20 minutes remaining.
A free-kick from the left of the area found an unmarked Danny Pugh whose shot was backheeled in by Rodolph Austin.
Everton clawed their way back into the game with nine minutes remaining when Victor Anichebe's cross into the box found Sylvain Distin whose header looped into the net, but they could not muster an equaliser.
Compared to the excitement in West Yorkshire, all that was in doubt at Stamford Bridge was the number of goals Chelsea would score as they hammered Wolves 6-0.
The writing was on the wall for the Championship side as they were three goals down within 17 minutes thanks to strikes by Gary Cahill, Ryan Bertrand and Juan Mata. An Oriol Romeu penalty (53), Fernando Torres (58) and Victor Moses (71) saw the Blues ease to the next round.
Two moments of individual magic proved enough for 10-man Sunderland to see off a spirited MK Dons side 2-0 at Stadium:mk.
The game lacked quality for large periods but two second-half goals, a fantastic Craig Gardner free-kick and a well-taken solo effort from James McClean, secured safe passage for Sunderland.
Wigan enjoyed an emphatic 4-1 victory at West Ham. There was little sign of what was to come when Modibo Maiga gave the Hammers an early lead. Two goals by Mauro Boselli, an Ivan Ramis strike and a Jordi Gomez penalty eased Roberto Martinez's side through.
A last-minute goal by Garry Monk saw Swansea secure a hard-earned 3-2 win at Crawley. The Premier League side went ahead through a fierce Miguel Michu shot after 27 minutes before the hosts levelled through Josh Simpson just before half-time.
The League One team then took the lead thanks to Hope Akpan 17 minutes into the second half, only for the Swans to equalise 12 minutes later through Danny Graham's close-range header.
With extra-time looming, Crawley were just found wanting as Monk headed home Wayne Routledge's corner.
Jay Rodriguez scored in the 30th minute and with a penalty 12 minutes from time as Southampton beat Championship side Sheffield Wednesday 2-0 at St Mary's.
Elsewhere, there was a 3-1 victory for Swindon against Burnley, while Middlesbrough defeated Preston by the same scoreline.
In the other game of the day to go to extra-time, Bradford ended Burton Albion's resistance thanks to Stephen Darby's goal.