| Date | GMT/BST | Home | Away | HT | Attend. | |||
|---|---|---|---|---|---|---|---|---|
| March 2012 | ||||||||
| Sat 10 | 23:00 | Colorado | 2-0 | Columbus | 1-0 | 14,746 | Report | |
| Sat 24 | 20:00 | Columbus | 2-0 | Montreal Impact | 1-0 | 18,197 | Eastern Conf | Report |
| Sat 31 | 19:00 | Toronto FC | 0-1 | Columbus | 0-0 | 18,944 | Eastern Conf | Report |
| April 2012 | ||||||||
| Sat 7 | 20:00 | Columbus | 1-4 | New York Red Bulls | 0-3 | 11,516 | Eastern Conf | Report |
| Sat 14 | 20:30 | Philadelphia Union | 1-0 | Columbus | 1-0 | 18,526 | Eastern Conf | Report |
| Sat 21 | 00:30 | Columbus | 2-2 | Houston | 0-0 | 10,479 | Eastern Conf | Report |
| Sat 28 | 00:30 | Columbus | 0-1 | Vancouver Whitecaps | 0-0 | 11,978 | Report | |
| May 2012 | ||||||||
| Sun 6 | 03:30 | Portland Timbers | 0-0 | Columbus | 0-0 | 20,438 | Report | |
| Sat 12 | 00:30 | Columbus | 2-1 | FC Dallas | 0-1 | 11,120 | Report | |
| Sun 20 | 03:30 | San Jose | 1-1 | Columbus | 0-1 | 10,256 | Report | |
| Thu 24 | 03:00 | Seattle Sounders FC | 0-2 | Columbus | 0-1 | 38,311 | Report | |
| Sat 26 | 00:00 | Columbus | 2-1 | Chicago | 2-0 | 16,024 | Eastern Conf | Report |
| June 2012 | ||||||||
| Sat 16 | 00:30 | New England | 0-0 | Columbus | 0-0 | 12,218 | Eastern Conf | Report |
| Sat 23 | 01:30 | Chicago | 2-1 | Columbus | 2-1 | 17,144 | Eastern Conf | Report |
| Sat 30 | 01:00 | Columbus | 2-0 | Real Salt Lake | 2-0 | 19,674 | Report | |
| July 2012 | ||||||||
| Sun 8 | 00:30 | Montreal Impact | 2-1 | Columbus | 0-0 | 15,118 | Eastern Conf | Report |
| Sat 14 | 00:30 | Columbus | 0-2 | Kansas City | 0-1 | 17,588 | Eastern Conf | Report |
| Sat 21 | 00:30 | Columbus | 1-0 | DC United | 0-0 | 17,150 | Eastern Conf | Report |
| Sun 29 | 01:30 | Kansas City | 1-2 | Columbus | 1-2 | 18,938 | Eastern Conf | Report |
| August 2012 | ||||||||
| Sat 4 | 00:30 | DC United | 1-0 | Columbus | 0-0 | 14,640 | Eastern Conf | Report |
| Wed 15 | 00:00 | Columbus | 1-1 | Los Angeles | 0-0 | 17,019 | Report | |
| Sun 19 | 02:00 | Houston | 2-2 | Columbus | 1-1 | 20,567 | Eastern Conf | Report |
| Wed 22 | 00:30 | Columbus | 2-1 | Toronto FC | 1-0 | 10,049 | Eastern Conf | Report |
| Sat 25 | 00:30 | Columbus | 4-3 | New England | 3-2 | 13,651 | Eastern Conf | Report |
| Thu 30 | 01:00 | Philadelphia Union | 1-2 | Columbus | 1-1 | 16,568 | Eastern Conf | Report |
| September 2012 | ||||||||
| Sat 1 | 00:30 | Columbus | 2-1 | Montreal Impact | 0-0 | 12,522 | Eastern Conf | Report |
| Thu 6 | 01:00 | New England | 2-0 | Columbus | 0-0 | 10,345 | Eastern Conf | Report |
| Sat 15 | 00:00 | New York Red Bulls | 3-1 | Columbus | 1-1 | 17,134 | Eastern Conf | Report |
| Wed 19 | 00:30 | Columbus | 1-0 | Chivas USA | 0-0 | 13,874 | Report | |
| Sat 22 | 01:30 | Chicago | 2-1 | Columbus | 2-1 | 19,172 | Eastern Conf | Report |
| Sat 29 | 00:30 | Columbus | 3-2 | Philadelphia Union | 2-0 | 14,673 | Eastern Conf | Report |
| October 2012 | ||||||||
| Sun 7 | 21:00 | Columbus | 1-1 | Kansas City | 0-1 | 13,566 | Eastern Conf | Report |
| Sat 20 | 00:30 | DC United | 3-2 | Columbus | 1-2 | 19,647 | Eastern Conf | Report |
| Sun 28 | 20:00 | Columbus | 2-1 | Toronto FC | 1-1 | 15,672 | Report | |
