Samir Nasri could not capitalise on the opportunity to fire Sevilla closer to La Liga leaders Real Madrid as they settled for a goalless draw with Villarreal on Sunday.
The former Arsenal midfielder saw his 49th-minute spot kick saved by goalkeeper Sergio Asenjo and third-placed Sevilla could not find a breakthrough.
In a tight encounter, Nasri was handed his chance when Sevilla skipper Vitolo was fouled by defender Mario, but his penalty was kept out by Asenjo.
The visitors gave as good as they got for long periods with Jonathan dos Santos, Samu Castillejo and Adrian Lopez all going close, but Wissam Ben Yedder, Pablo Sarabia and Vicente Iborra forced saves as the home side pushed for the breakthrough.
Real Sociedad climbed to within a point of the top four courtesy of a hard-fought 3-2 victory over lowly Osasuna.
The visitors, who started the day sitting in 19th place in the table, went ahead through Kenan Kodro's 25th-minute strike and retained their lead until 17 minutes after the break when Raul Navas levelled with a header.
Carlos Vela fired Sociedad in front 10 minutes later and Juanmi made it 3-1 with 13 minutes remaining, although Sergio Leon ensured a tense conclusion when he reduced the deficit within two minutes.
Christian Santos and Edgar Mendez both struck from the spot as Alaves dumped Sporting Gijon deeper into relegation trouble after a six-goal thriller at El Molinon.
The visitors were cruising when Ruben Sobrino, Santos and Mendez put them 3-0 up with 20 minutes remaining, but that was far from the end of the action.
Substitute Lacina Traore pulled one back for the home side with six minutes left and Carlos Castro struck again at the death, but not before defender Alexis had added a fourth for Alaves to seal a 4-2 win.